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They may reactwith carboxyl, hydroxyl, amino, sulfhydryl andphosphate groups of biomacromolecules.Alkylation results in cross linking/abnormal basepairing/scission of DNA strand.

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Pressure reactivity as a guide in the treatment of cerebral perfusionpressure in patients with brain trauma. Inasmuch as thrombosis in atheroscle-rotic vessels plays a key role in major CAD events,these effects may be important factors in alcohol’sprotection.

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However in spiteof early S phase entry, the lung cells from p53-null MDM2 transgenic mice showfewer DNA replication origin ?ring events compared to lung cells from p53-nullmice at the onset of S phase [ 25].

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