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They may reactwith carboxyl, hydroxyl, amino, sulfhydryl andphosphate groups of biomacromolecules.Alkylation results in cross linking/abnormal basepairing/scission of DNA strand.
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However in spiteof early S phase entry, the lung cells from p53-null MDM2 transgenic mice showfewer DNA replication origin ?ring events compared to lung cells from p53-nullmice at the onset of S phase [ 25].
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