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Indeed, a number of other E3 ligases were shown to regulate p53 pro-tein levels in tissue culture and in biochemical studies in vitro, these include: Pirh2[50], Cop1 [51], and Arf-BP1 [52], ICP0 [53], TOPORS [54], CHIP [55], Ubc13[56], Synoviolin [57], E4F1 [58], CARP1 [59], CARP2 [59], WWP1 [60], MSL2[61], (also reviewed in [62, 25, 21]).

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